Unresolved chronic pain cases should consider an evaluation for RIT / prolotherapy if the patient has not achieved desired improvement with physical therapy. Candidates also include those who can not tolerate long-term pain medication use and those wishing to prevent or delay surgical procedures. RIT may improve or alleviate pain conditions even when physical therapy, medications, surgery, chiropractic, acupuncture, cortisone, or prolotherapy treatments have failed or only marginally improved conditions.